HK2 Monoclonal Antibody

SKU: BT-MCA2955

Size:100μL

Background:The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose- 6-phosphate. Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK). Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases .Hexokinase 2 is the predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

Research_area:Signal transduction, Cancer, Metabolism, Cardiovascular

Target_protein:HK2

applications:WB, IHC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:3D3

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:HK2

Immunogen:Purified recombinant fragment of human HK2 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):102kDa

UniProt accession:P52789

Synonyms:HKII, HXK2, DKFZp686M1669, HK2

GeneID:3099