HIF1A Monoclonal Antibody

SKU: BT-MCA2309

Size:100μL

Background:Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. (provided by RefSeq) Tissue specificity: Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors.

Research_area:Cardiovascular

Target_protein:HIF1A

applications:WB, IHC, ICC

Reactivity:Human, Mouse, Monkey

Clonality:Monoclonal

Clone ID:1A3

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:HIF1A

Immunogen:Purified recombinant fragment of human HIF1A expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):120kDa

UniProt accession:Q16665

Synonyms:HIF1, MOP1, PASD8, bHLHe78, HIF-1alpha, HIF1-ALPHA, HIF1A

GeneID:3091