HEY1 antibody , Cat. # FNab03849

SKU: FNab03849

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737).

Immunogen:hairy/enhancer-of-split related with YRPW motif 1

Synonyms:BHLHB31, CHF2, HERP2, HESR1, HRT1

Observed MW:33 kDa

Uniprot ID:Q9Y5J3

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC, IP

Recommended dilution:WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200

Gene ID:23462

Research Area:Cardiovascular, Metabolism, Developmental biology