HCFC1 Antibody - Cat. #: CSB-PA914205

SKU: CSB-PA914205

Size :100ul

Clone Number:

Aliases:C1 factor antibody; CFF antibody; HCF 1 antibody; HCF antibody; HCF C-terminal chain 6 antibody; HCF-1 antibody; HCF1 antibody; Hcfc1 antibody; HCFC1_HUMAN antibody; HFC1 antibody; Host cell factor 1 antibody; Host cell factor antibody; Host cell factor C1 (VP16 accessory protein) antibody; Host cell factor C1 antibody; MGC70925 antibody; MRX3 antibody; VCAF antibody; VP16 accessory protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P51610

Immunogen:Synthesized peptide derived from N-terminal of Human HCFC1.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, IHC; IHC:1:50-1:100

Background:Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.

Wilson A.C., Cell 74:115-125(1993).
Kristie T.M., J. Biol. Chem. 270:4387-4394(1995).
Ross M.T., Nature 434:325-337(2005).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:HCFC1

Research Areas:Epigenetics and Nuclear Signaling;Cell biology;Microbiology