Granulin/GRN/Progranulin Monoclonal Antibody

SKU: AN200186P

Size::20μL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:GRN

Target Synonym:CLN;GRN;CLN11;GEP;GP88;PCDGF;PEPI;PGRN;granulins;Granulin;PC cell-derived growth factor;proepithelin;Progranulin

Research Areas:Neuroscience;Immunology;Cancer

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:ICC/IF

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:10F6

UNIProt ID:P28799

Accession:

Background:Progranulin, also known as acrogranin, PC cell-derived growth factor (PCDGF) and epithelin/granulin precursor, is a ubiquitously expressed, 88 kDa, secreted glycoprotein. Structurally, it belongs to none of the well-established growth factor families. Mouse Progranulin is 589 amino acids (aa) in length and contains a 17 aa signal sequence and a 572 aa mature region that has four potential sites for N-linked glycosylation. It has a highly repetitive organization, containing seven tandem copies of a 55‑57 aa consensus motif that contains 12 conserved cysteine residues: VxCx5-6Cx5CCx8CCx6CCxDx2HCCPx4Cx5-6Cx2. Progranulin is secreted in an intact form or undergoes proteolysis leading to the release of multiple peptides made from the seven tandem repeats, the granulins. Mouse Progranulin shares 87% and 75% aa sequence identity with rat and human Progranulin, respectively. Progranulin is involved in the regulation of cellular proliferation, as well as differentiation, development, and pathological processes. It has been isolated as a differentially expressed gene during mesothelial differentiation, macrophage development, development synovium of rheumatoid arthritis and osteoarthritis, sexual differentiation of the brain, and has also been shown to be a mediator of cartilage proliferation plus of wound response and tissue repair. High levels of Progranulin expression have been found to be associated with several human cancers, and are believed to contribute to tumorigenesis in breast cancer, clear cell renal carcinoma, invasive ovarian carcinoma, glioblastoma, adipocyte teratoma, and multiple myeloma.

Concentration:1 mg/mL

Immunogen:Recombinant Human Granulin protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:ICC/IF 1:20-1:100

Calculated MW:

ObservedMW: