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Gene Bio Systems

GNA12 Antibody, Biotin conjugated - Cat. #: CSB-PA009584LD01HU

GNA12 Antibody, Biotin conjugated - Cat. #: CSB-PA009584LD01HU

CSB-PA009584LD01HU

$484.78 CAD
$484.78 CAD
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Size :50ug

Clone Number:

Aliases:G alpha 12 antibody; G alpha-12 antibody; G-protein subunit alpha-12 antibody; gep antibody; Gna12 antibody; GNA12_HUMAN antibody; guanine nucleotide binding protein (G protein) alpha 12 antibody; Guanine nucleotide binding protein alpha 12 subunit antibody; Guanine nucleotide-binding protein subunit alpha-12 antibody; MGC104623 antibody; MGC99644 antibody; NNX3 antibody; RMP antibody; WUGSC:H_GS165O14.2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q03113

Immunogen:Recombinant Human Guanine nucleotide-binding protein subunit alpha-12 protein (112-270AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:GNA12

Research Areas:Signal transduction

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