GLIS2 Antibody, HRP conjugated - Cat. #: CSB-PA861185LB01HU

SKU: CSB-PA861185LB01HU

Size :50ug

Clone Number:

Aliases:FLJ38247 antibody; GLI similar 2 antibody; GLI-similar 2 antibody; GLIS 2 antibody; GLIS family zinc finger 2 antibody; glis2 antibody; GLIS2_HUMAN antibody; Kruppel like zinc finger protein GLIS2 antibody; Neuronal Krueppel-like protein antibody; Zinc finger protein GLIS2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9BZE0

Immunogen:Recombinant Human Zinc finger protein GLIS2 protein (332-505AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:GLIS2

Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Signal transduction; Stem cells