GDNF Polyclonal Antibody

SKU: E-AB-70291

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:GDNF

Target Synonym:Astrocyte derived trophic factor;Astrocyte derived trophic factor 1;Astrocyte-derived trophic factor;ATF 1;ATF 2;Atf;ATF1;ATF2;gdnf;GDNF;Glial cell derived neurotrophic factor;Glial Cell Line Derived Neurotrophic Factor;Glial cell line-derived neurotrophic factor;Glial derived neurotrophic factor;HFB1 GDNF;hGDNF;HSCR3

Research Areas:Neuroscience;Developmental Biology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q07731,P48540

Accession:

Background:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing.

Concentration:80 μg/mL

Immunogen:KLH conjugated Synthetic peptide corresponding to mouse GDNF

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification method:Affinity purification

Dilution:IHC 1:100-1:500

Calculated MW:

ObservedMW: