FZR1 Antibody, HRP conjugated - Cat. #: CSB-PA892473LB01HU

SKU: CSB-PA892473LB01HU

Size :50ug

Clone Number:

Aliases:CDC20 like 1b antibody; CDC20 like protein 1 antibody; CDC20-like protein 1 antibody; CDC20C antibody; CDH1 antibody; Cdh1/Hct1 homolog antibody; Fizzy related protein 1 antibody; Fizzy related protein antibody; Fizzy related protein homolog antibody; Fizzy-related protein homolog antibody; Fizzy/cell division cycle 20 related 1 antibody; FYR antibody; FZR 1 antibody; FZR 2 antibody; Fzr antibody; FZR_HUMAN antibody; Fzr1 antibody; Fzr1 protein antibody; FZR2 antibody; HCDH 1 antibody; HCDH antibody; hCDH1 antibody; KIAA1242 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UM11

Immunogen:Recombinant Human Fizzy-related protein homolog protein (1-493AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FZR1

Research Areas:Cell biology