FRS2 (Ab-196) Antibody - Cat. #: CSB-PA208276

SKU: CSB-PA208276

Size :100ul

Clone Number:

Aliases:FGFR signaling adaptor SNT antibody; FGFR signalling adaptor antibody; FGFR substrate 2 antibody; FGFR-signaling adaptor SNT antibody; Fibroblast growth factor receptor substrate 2 antibody; FRS 2 antibody; FRS2 antibody; FRS2_HUMAN antibody; FRS2A antibody; FRS2alpha antibody; SNT 1 antibody; SNT antibody; SNT-1 antibody; SNT1 antibody; Suc 1 Associated Neurotrophic Factor Target antibody; Suc1 associated neurotrophic factor target 1 antibody; Suc1-associated neurotrophic factor target 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8WU20

Immunogen:Synthesized non-phosphopeptide derived from Human FRS2 around the phosphorylation site of tyrosine 196 (H-T-Y(p)-V-N).

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

The MGC Project Team; Genome Res. 14:2121-2127(2004).
Xu H., J. Biol. Chem. 273:17987-17990(1998).
Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FRS2

Research Areas:Signal transduction