FLT3 Polyclonal Antibody

SKU: E-AB-10844

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:FLT3

Target Synonym:CD 135;CD135;CD135 antigen;Fetal liver kinase 2;FL cytokine receptor;Flk 2;Flk2;Flt 3;FLT-3;Flt3;FLT3;FMS like tyrosine kinase 3;Fms related tyrosine kinase 3;Fms-like tyrosine kinase 3;Growth factor receptor tyrosine kinase type III;Ly-72;OTTHUMP0000004234;Receptor type tyrosine protein kinase FLT3;Stem cell tyrosine kinase 1;Stk 1;STK-1;Stk1;Tyrosine protein kinase receptor FLT3;Tyrosine-protein kinase receptor FLT3

Research Areas:Immunology;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P36888

Accession:

Background:This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Concentration:0.5 mg/mL

Immunogen:Recombinant protein of human FLT3

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:IHC 1:50-1:200

Calculated MW:

ObservedMW: