FHIT Antibody - Cat. #: CSB-PA105645

SKU: CSB-PA105645

Size :100ul

Clone Number:

Aliases:FHITBis(5'-adenosyl)-triphosphatase antibody; EC 3.6.1.29 antibody; AP3A hydrolase antibody; AP3Aase antibody; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase antibody; Dinucleosidetriphosphatase antibody; Fragile histidine triad protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P49789

Immunogen:Synthesized peptide derived from Human FHIT.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

Background:Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+ transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

Hideshi Ishii, Cancer Res., Dec 2006; 66: 11287 - 11292.
Francesca Bianchi, PNAS, Dec 2006; 103: 18981 - 18986.
Koshi Mimori, Cancer Res., Mar 2006; 66: 2683 - 2690.
Tamotsu Kuroki, Cancer Res., Jul 2003; 63: 3724 - 3728.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FHIT

Research Areas:Epigenetics and Nuclear Signaling;Cancer