FADD Antibody - Cat. #: CSB-PA221364

SKU: CSB-PA221364

Size :50ul

Clone Number:

Aliases:FADD antibody; FADD protein antibody; FADD_HUMAN antibody; Fas (TNFRSF6) associated via death domain antibody; Fas associated via death domain antibody; Fas associating death domain containing protein antibody; Fas associating protein antibody; Fas associating protein with death domain antibody; Fas TNFRSF6 associated via death domain antibody; FAS-associated death domain protein antibody; FAS-associating death domain-containing protein antibody; GIG 3 antibody; GIG3 antibody; Growth inhibiting gene 3 protein antibody; Growth-inhibiting gene 3 protein antibody; H sapiens mRNA for mediator of receptor induced toxicity antibody; Mediator of receptor induced toxicity antibody; MGC8528 antibody; MORT 1 antibody; MORT1 antibody; Protein FADD antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13158

Immunogen:Fusion protein of Human FADD

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; ELISA:1:1000-1:5000, IHC:1:50-1:150

Background:The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FADD

Research Areas:Cancer;Cell biology