EYA4 antibody , Cat. # FNab02916

SKU: FNab02916

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX(H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye(By similarity).

Immunogen:eyes absent homolog 4(Drosophila)

Synonyms:

Observed MW:67 kDa

Uniprot ID:O95677

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IF

Recommended dilution:WB: 1:500-1:2000; IF: 1:20-1:200

Gene ID:2070

Research Area:Neuroscience, Cardiovascular, Metabolism, Developmental biology