ERBB2 Antibody, Biotin conjugated - Cat. #: CSB-PA09759D0Rb

SKU: CSB-PA09759D0Rb

Size :50ug

Clone Number:

Aliases:Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody; C erb B2/neu protein antibody; CD340 antibody; CD340 antigen antibody; Cerb B2/neu protein antibody; CerbB2 antibody; Erb b2 receptor tyrosine kinase 2 antibody; ErbB-2 proto-oncogene antibody; ERBB2 antibody; ERBB2_HUMAN antibody; HER 2 antibody; HER 2/NEU antibody; HER2 antibody; Herstatin antibody; Human epidermal growth factor receptor 2 antibody; Metastatic lymph node gene 19 protein antibody; MLN 19 antibody; MLN19 antibody; NEU antibody; NEU proto oncogene antibody; Neuro/glioblastoma derived oncogene homolog antibody; Neuroblastoma/glioblastoma derived oncogene homolog antibody; NGL antibody; p185erbB2 antibody; Proto-oncogene c-ErbB-2 antibody; Proto-oncogene Neu antibody; Receptor tyrosine-protein kinase erbB-2 antibody; TKR1 antibody; Tyrosine kinase type cell surface receptor HER2 antibody; Tyrosine kinase-type cell surface receptor HER2 antibody; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody; V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody; V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody; V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody; Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P04626

Immunogen:Recombinant Human Receptor tyrosine-protein kinase erbB-2 protein (153-598AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ERBB2

Research Areas:Cancer; Tags & Cell Markers; Immunology; Signal transduction