Endoglin/CD105 antibody , Cat. # FNab02761

SKU: FNab02761

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen:endoglin

Synonyms:CD105, END, Endoglin, ENG, FLJ41744, HHT1, ORW, ORW1

Observed MW:68-75 kDa, 170-180 kDa

Uniprot ID:P17813

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IP, IHC

Recommended dilution:WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:2000-1:8000

Gene ID:2022

Research Area:Signal Transduction, Cardiovascular, Immunology, Cancer, Developmental biology, Stem Cells