ELANE Polyclonal Antibody

SKU: E-AB-17904

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: ELANE

Target Synonym: Bone marrow serine protease;ELA2;ELANE;Elastase 2;Elastase 2 neutrophil ;Elastase neutrophil expressed;Elastase-2;ELNE;GE;Granulocyte derived elastase;HLE;HNE;Human leukocyte elastase;Leukocyte elastase;Medullasin;NE;Neutrophil elastase;PMN E;PMN elastase;Polymorphonuclear elastase;SCN1

Research Areas: Cancer;Immunology;Microbiology;Signal transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P08246

Accession:

Background: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.

Concentration: 0.9 mg/mL

Immunogen: Synthetic peptide of human ELANE

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:30-1:150

Calculated MW:

ObservedMW: