EDARADD Polyclonal Antibody

SKU: E-AB-52310

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: EDARADD

Target Synonym: Cr;Crinkled homolog;ectodysplasia A receptor associated death domain;Ectodysplasin-A receptor-associated adapter protein;ED3;EDA3;EDAD;EDAR associated death domain;EDAR-associated death domain protein;EDARADD;Protein crinkled homolog

Research Areas: Epigenetics and Nuclear Signaling;Developmental biology;Signal transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q8WWZ3

Accession:

Background: This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Concentration: 0.9 mg/mL

Immunogen: Full length fusion protein

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:35-1:200

Calculated MW:

ObservedMW: