EAAT2 rabbit pAb

SKU: ES20771

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human;Rat;Mouse

Dilution:WB 1:1000-2000

Immunogen:Synthetic Peptide of EAAT2 AA range: 370-420

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):62kD

Human_gene_id:6506

Human_swiss_prot_no:P43004

Subcellular_location:Cell membrane ; Multi-pass membrane protein .

Other_name:Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)

Background:This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],