E2F4 Antibody - Cat. #: CSB-RA179313A0HU

SKU: CSB-RA179313A0HU

Size :50ul

Clone Number:24E12

Aliases:Transcription factor E2F4 (E2F-4), E2F4

Product Type:Recombinant Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q16254

Immunogen:A synthesized peptide derived from human E2F4

Raised in:

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF, FC; Recommended dilution: IHC:1:50-1:200, IF:1:50-1:200, FC:1:50-1:200

Background:Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}.

Clonality:Monoclonal

Isotype:Rabbit IgG

Purification Method:Affinity-chromatography

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:E2F4

Research Areas:Epigenetics and Nuclear Signaling; Stem cells