E2F1 Monoclonal Antibody

SKU: BT-MCA4272

Size:100μL

Background:The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Research_area:Epigenetics and Nuclear Signaling

Target_protein:E2F1

applications:WB, IHC, FCM

Reactivity:Human, Mouse

Clonality:Monoclonal

Clone ID:8G9

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:E2F1

Immunogen:Purified recombinant fragment of human E2F1 (AA: 69-223) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):46.9kDa

UniProt accession:Q01094

Synonyms:RBP3, E2F-1, RBAP1, RBBP3

GeneID:1869