DNase-Ⅰ Polyclonal Antibody

SKU: D-AB-10417L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:DNase-Ⅰ

Target Synonym:Deoxyribonuclease-1;Deoxyribonuclease I;DNase I;Dornase alfa;DNASE1;DNL1; DRNI

Research Areas:Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P24855

Accession:

Background:DNase1,also known as deoxyribonuclease I and DNL1,is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide,yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3',on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations in DNase1 gene have been associated with systemic lupus erythematosus (SLE),an autoimmune disease. DNase1 is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity.

Concentration:1 mg/mL

Immunogen:Recombinant Human DNase-Ⅰ protein expressed by Mammalian

Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4

Purification method:Antigen Affinity Purification

Dilution:WB 1:500-1:1000

Calculated MW:31kDa

ObservedMW:43kDa