DESP rabbit pAb

SKU: ES16958

Size: 100μL

Source:Rabbit

Applications:IHC;IF

Reactivity:Human; Mouse

Dilution:IHC-p 1：50-200

Immunogen:Synthesized peptide derived from human DESP AA range: 1546-1596

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):

Human_gene_id:1832

Human_swiss_prot_no:P15924

Subcellular_location:Cell junction, desmosome . Cytoplasm, cytoskeleton . Cell membrane . Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network (PubMed:12802069). Localizes at the intercalated disk in cardiomyocytes (By similarity). .

Other_name:

Background:This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],