DDX58 Antibody, FITC conjugated - Cat. #: CSB-PA006638LC01HU

SKU: CSB-PA006638LC01HU

Size :50ug

Clone Number:

Aliases:Ddx58 antibody; DDX58_HUMAN antibody; DEAD (Asp Glu Ala Asp) box polypeptide 58 antibody; DEAD (Asp Glu Ala Asp/His) box polypeptide antibody; DEAD box protein 58 antibody; DEAD/H (Asp Glu Ala Asp/His) box polypeptide RIG1 antibody; DKFZp434J1111 antibody; DKFZp686N19181 antibody; FLJ13599 antibody; Probable ATP dependent RNA helicase DDX58 antibody; Probable ATP-dependent RNA helicase DDX58 antibody; Retinoic acid inducible gene 1 protein antibody; Retinoic acid-inducible gene 1 protein antibody; Retinoic acid-inducible gene I protein antibody; RIG I antibody; Rig-1 antibody; RIG-I antibody; RIG1 antibody; rigi antibody; RLR 1 antibody; RNA helicase antibody; RNA helicase RIG I antibody; SGMRT2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O95786

Immunogen:Recombinant Human Probable ATP-dependent RNA helicase DDX58 protein (1-430AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:nnate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5\'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5\'-triphosphate moiety, blunt-end base pairing at the 5\'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3\'overhang at the 5\'triphosphate end decreases and any 5\'overhang at the 5\' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DDX58

Research Areas:Epigenetics and Nuclear Signaling; Immunology