Cyclin E1(Phospho-Thr62) Rabbit Polyclonal Antibody

SKU: BT-AP08846

Size:100μL

Background:The protein encoded by this gene belongs to the highly conserved cyclin family| whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2| whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors| which results in chromosome instability| and thus may contribute to tumorigenesis. This protein was found to associate with| and be involved in| the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus)| which participates in

Research_area:Cancer; Cell biology; Epigenetics and nuclear signaling

Target_protein:CCNE1

applications:WB

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Cyclin E1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: P24864; Mouse: Q61457; Rat: P39949

Synonyms:Cyclin E1 ;Thr62; G1/S-specific cyclin-E1

GeneID:Human: 898; Mouse: 12447