CXADR Antibody - Cat. #: CSB-PA830526

SKU: CSB-PA830526

Size :100ul

Clone Number:

Aliases:46 kD coxsackievirus and adenovirus receptor CAR protein antibody; 46 kD coxsackievirus and adenovirus receptor protein antibody; CAR antibody; CAR4/6 antibody; Coxsackie virus and adenovirus receptor antibody; Coxsackie virus B receptor antibody; Coxsackievirus and adenovirus receptor antibody; Coxsackievirus B adenovirus receptor antibody; Coxsackievirus B-adenovirus receptor antibody; CVB3 binding protein antibody; CVB3-binding protein antibody; Cxadr antibody; CXADR Ig like cell adhesion molecule antibody; CXAR_HUMAN antibody; hCAR antibody; HCVADR antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P78310

Immunogen:Synthesized peptide derived from internal of Human CXADR.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

Tomko R.P., Proc. Natl. Acad. Sci. U.S.A. 94:3352-3356(1997).
Bergelson J.M., Science 275:1320-1323(1997).
Bowles K.R., Hum. Genet. 105:354-359(1999).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CXADR

Research Areas:Microbiology?Signal transduction