CTCF Monoclonal Antibody

SKU: BT-MCA3983

Size:100μL

Background:This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes.

Research_area:Epigenetics and nuclear signaling

Target_protein:CTCF

applications:WB

Reactivity:Human, Monkey

Clonality:Monoclonal

Clone ID:1D11

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CTCF

Immunogen:Purified recombinant fragment of human CTCF expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):83kDa

UniProt accession:P49711

Synonyms:CTCF

GeneID:10664