Crystallin-αC rabbit pAb

SKU: ES20776

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human

Dilution:WB: 1:500-1000

Immunogen:Recombinant Protein of Crystallin-αC

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:

Observed_band(KD):22kD

Human_gene_id:26353

Human_swiss_prot_no:Q9UJY1

Subcellular_location:Cytoplasm . Nucleus . Translocates to nuclear foci during heat shock.

Other_name:HSPB8; CRYAC; E2IG1; HSP22; PP1629; Heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22

Background:The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008],