CRTC3 Monoclonal Antibody

SKU: BT-MCA4191

Size:100μL

Background:Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.

Research_area:Epigenetics and nuclear signaling, Microbiology

Target_protein:CRTC3

applications:WB, IHC, ICC

Reactivity:Human, Monkey

Clonality:Monoclonal

Clone ID:5G9

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CRTC3

Immunogen:Purified recombinant fragment of human CRTC3 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):68kDa

UniProt accession:Q6UUV7

Synonyms:TORC3, FLJ21868, CRTC3

GeneID:64784