Crk II(Phospho Tyr221) Polyclonal Antibody

SKU: BT-AP08108

Size:100μL

Background:This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Research_area:Cancer; Signal transduction

Target_protein:CRK

applications:WB, IF, ICC, ELISA

Reactivity:Human, Mouse, Rat, Monkey

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Adapter molecule crk

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):33872

UniProt accession:Human: P46108; Mouse: Q64010; Rat: Q63768

Synonyms:Adapter molecule crk; CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38

GeneID:Human: 1398; Mouse: 12928; Rat: 54245