COL4A1 Antibody - Cat. #: CSB-PA975386

SKU: CSB-PA975386

Size :100ul

Clone Number:

Aliases:Arresten antibody; BSVD antibody; CO4A1_HUMAN antibody; COL4A1 antibody; COL4A1 NC1 domain antibody; COL4A2 antibody; COL4A3 antibody; COL4A4 antibody; COL4A5 antibody; collagen alpha-1(IV) chain antibody; Collagen IV Alpha 1 Polypeptide antibody; Collagen IV Alpha 2 Polypeptide antibody; Collagen Of Basement Membrane Alpha 1 Chain antibody; Collagen Of Basement Membrane Alpha 2 Chain antibody; Collagen Type IV Alpha 1 antibody; collagen type IV alpha 1 chain antibody; Collagen Type IV Alpha 2 antibody; Collagen Type IV Alpha 3 antibody; Collagen Type IV Alpha 4 antibody; Collagen Type IV Alpha 5 antibody; RATOR antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P02462

Immunogen:Synthesized peptide derived from Human Collagen IV.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.

Mary K. Chelberg, Cancer Res., Sep 1989; 49: 4796 - 4802.
Patricia L. Graham, J. Cell Biol., Jun 1997; 137: 1171.
PJ Lein, J. Cell Biol., Apr 1991; 113: 417.
EC Tsilibary, J. Biol. Chem., Dec 1988; 263: 19112 - 19118.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:COL4A1

Research Areas:Others