Cobra venom factor Antibody - Cat. #: CSB-PA856221LA01NAF

SKU: CSB-PA856221LA01NAF

Size :50ug

Clone Number:

Aliases:antibody; Cobra venom factor antibody; CVF antibody; CVFk antibody; Complement C3 homolog) [Cleaved into: Cobra venom factor alpha chain; Cobra venom factor gamma chain; Cobra venom factor beta chain] antibody

Product Type:Polyclonal Antibody

Immunogen Species:Naja kaouthia

UniProt ID:Q91132

Immunogen:Recombinant Naja kaouthia Cobra venom factor protein (733-984AA)

Raised in:Rabbit

Species Reactivity:Naja kaouthia

Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background:Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:

Research Areas:Others