CMKLR1 Antibody - Cat. #: CSB-PA140333

SKU: CSB-PA140333

Size :100ul

Clone Number:

Aliases:CHEMERINR antibody; Chemokine like receptor 1 antibody; Chemokine-like receptor 1 antibody; CHEMR23 antibody; CMKLR1 antibody; CML1_HUMAN antibody; DEZ antibody; G protein coupled receptor ChemR23 antibody; G protein coupled receptor DEZ antibody; G-protein coupled receptor ChemR23 antibody; G-protein coupled receptor DEZ antibody; Orphan G protein coupled receptor antibody; Orphan G protein coupled receptor Dez antibody; Resolvin E1 receptor antibody; RVER1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q99788

Immunogen:Synthesized peptide derived from internal of Human CMKLR1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

Methner A., Biochem. Biophys. Res. Commun. 233:336-342(1997).
Samson M., Eur. J. Immunol. 28:1689-1700(1998).
Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CMKLR1

Research Areas:Cell biology;Signal transduction