CLK2 Antibody - Cat. #: CSB-PA562044

SKU: CSB-PA562044

Size :100ul

Clone Number:

Aliases:CDC like kinase 2 antibody; CDC-like kinase 2 antibody; CLK 2 antibody; CLK kinase antibody; CLK2 antibody; Clk2 Scamp3 antibody; CLK2_HUMAN antibody; Dual specificity protein kinase CLK2 antibody; hCLK 2 antibody; hCLK2 antibody; Tu52 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P49760

Immunogen:Synthesized peptide derived from internal of Human CLK2.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Hanes J.J., J. Mol. Biol. 244:665-672(1994).
Winfield S.L., Genome Res. 7:1020-1026(1997).
Lee K., J. Biol. Chem. 271:27299-27303(1996).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CLK2

Research Areas:Epigenetics and Nuclear Signaling;Cell biology;Signal transduction