Claudin-5 (phospho Tyr217) rabbit pAb

SKU: ES7400

Size: 100μL

Source:Rabbit

Applications:IHC;IF;WB;ELISA

Reactivity:Human;Mouse;Rat

Dilution:WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Immunogen:The antiserum was produced against synthesized peptide derived from human Claudin 5 around the phosphorylation site of Tyr217. AA range:169-218

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):23kD

Human_gene_id:7122

Human_swiss_prot_no:O00501

Subcellular_location:Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Other_name:CLDN5; AWAL; TMVCF; Claudin-5; Transmembrane protein deleted in VCFS; TMDVCF

Background:This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008],