CHEK2 (Ab-516) Antibody - Cat. #: CSB-PA074742

SKU: CSB-PA074742

Size :100ul

Clone Number:

Aliases:CDS 1 antibody; Cds1 antibody; Cds1 homolog antibody; Checkpoint kinase 2 antibody; Checkpoint like protein CHK2 antibody; CHEK 2 antibody; Chek2 antibody; Chk 2 antibody; CHK2 checkpoint homolog (S. pombe) antibody; CHK2 checkpoint homolog antibody; CHK2_HUMAN antibody; hCds1 antibody; HuCds 1 antibody; LFS 2 antibody; LFS2 antibody; PP1425 antibody; RAD 53 antibody; RAD53 antibody; Rad53 homolog antibody; Serine/threonine protein kinase Chk2 antibody; Serine/threonine-protein kinase Chk2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O96017

Immunogen:Peptide sequence around aa. 514~518(Q-P-S-T-S) derived from Human Chk2.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

Melchionna, R. et al. (2000) Nat. Cell Biol. 2, 762-765.
Ahn, J.Y. et al. (2000) Cancer Res. 60, 5934-5936.
Lee, C.H. and Chung, J.H. (2001) J. Biol. Chem. 276, 30537-30541

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CHEK2

Research Areas:Epigenetics and Nuclear Signaling;Cancer