CDNF Polyclonal Antibody

SKU: D-AB-10383L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:CDNF

Target Synonym:Cerebral dopamine neurotrophic factor;ARMET-like protein 1;Conserved dopamine neurotrophic factor;CDNF;ARMETL1

Research Areas:Neuroscience

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Rat

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q49AH0

Accession:

Background:Cerebral Dopamine Neurotrophic Factor (CDNF),also known as ARMETL1 (ARMET-like protein 1),is a secreted protein with eight conserved cysteine residues,predicting a unique protein fold and defining a new,evolutionarily conserved protein family. CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease,suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex,hippocampus,substantia nigra,striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival,growth,and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.

Concentration:1 mg/mL

Immunogen:Recombinant Human CDNF protein expressed by Mammalian

Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4

Purification method:Antigen Affinity Purification

Dilution:WB 1:500-1:1000

Calculated MW:21kDa

ObservedMW:17kDa