CDH1 Monoclonal Antibody

SKU: BT-MCA2220

Size:100μL

Background:E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.

Research_area:Signal transduction, Cancer, Developmental biology

Target_protein:CDH1

applications:WB

Reactivity:Human, Mouse, Monkey

Clonality:Monoclonal

Clone ID:7A2

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CDH1

Immunogen:Purified recombinant fragment of human CDH1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):135kDa

UniProt accession:P12830

Synonyms:UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1

GeneID:999