CD59 Polyclonal Antibody

SKU: D-AB-10258L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:CD59

Target Synonym:16.3A5;1F5;1F5 antigen;20 kDa homologous restriction factor;CD 59;CD_antigen=CD59;CD59;CD59 antigen;CD59 antigen complement regulatory protein ;CD59 antigen p18 20;CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5;EJ16;EJ30;EL32 and G344);CD59 glycoprotein;CD59 molecule;CD59 molecule complement regulatory protein;CD59;Cd59a;Complement regulatory protein;EJ16;EJ30;EL32;FLJ38134;FLJ92039;G344;HRF 20;HRF-20;HRF20;Human leukocyte antigen MIC11;Ly 6 like protein;Lymphocytic antigen CD59/MEM43;MAC inhibitory protein;MAC IP;MAC-inhibitory protein;MAC-IP;MACIF;MACIP;MEM43;MEM43 antigen;Membrane attack complex (MAC) inhibition factor;Membrane attack complex inhibition factor;Membrane inhibitor of reactive lysis;MGC2354;MIC11;MIN1;MIN2;MIN3;MIRL;MSK21;p18 20;Protectin;Surface antigen recognized by monoclonal 16.3A5;T cell activating protein

Research Areas:Cancer;Cardiovascular;Immunology;Signal Transduction;Stem Cells

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P13987

Accession:

Background:This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction.

Concentration:1 mg/mL

Immunogen:Recombinant Human CD59 protein expressed by E.coli

Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4

Purification method:Antigen Affinity Purification

Dilution:WB 1:500-1:1000;IHC 1:250-1:500

Calculated MW:14kDa

ObservedMW:14-17kDa