CD283 Monoclonal Antibody

SKU: BT-MCA2970

Size:100μL

Background:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]

Research_area:Others

Target_protein:CD283

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:6F3G4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CD283

Immunogen:Purified recombinant fragment of human CD283 (AA: 24-217) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):103.8kDa

UniProt accession:O15455

Synonyms:TLR3 , IIAE2

GeneID:7098