Caspase 1 antibody , Cat. # FNab10015

SKU: FNab10015

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta(IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing.

Immunogen:caspase 1

Synonyms:CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, Interleukin 1 beta convertase, p10, p20, P45

Observed MW:45-47 kDa, 30 kDa, 35 kDa

Uniprot ID:P29466

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IHC

Recommended dilution:WB: 1:200-1:2000; IHC: 1:50-1:500

Gene ID:834

Research Area:Signal Transduction, Metabolism, Cardiovascular, Neuroscience