CASP1 Antibody - Cat. #: CSB-PA758068

SKU: CSB-PA758068

Size :50ul

Clone Number:

Aliases:CASP-1 antibody; CASP1 antibody; CASP1_HUMAN antibody; Caspase 1 antibody; Caspase-1 subunit p10 antibody; ICE antibody; IL-1 beta-converting enzyme antibody; IL-1BC antibody; IL1 beta converting enzyme antibody; IL1B convertase antibody; Interleukin 1 beta convertase antibody; Interleukin 1B converting enzyme antibody; Interleukin-1 beta convertase antibody; Interleukin-1 beta-converting enzyme antibody; p45 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P29466

Immunogen:Fusion protein of Human CASP1

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:10000, WB:1:1000-1:4000, IHC:1:25-1:100

Background:This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CASP1

Research Areas:Cancer;Cell biology;Metabolism