Canine Cystic Fibrosis Transmembrane Conductance Regulator, CFTR ELISA Kit

SKU: E0340Ca

Size:96 Tests-1 Kit

Background:Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).

Research_area:Cell Biology

Applications:ELISA

Target_protein:CFTR

Reactivity:Canine

Assay type:Sandwich

Sensitivity:4.99ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cystic fibrosis transmembrane conductance regulator

Species:Canine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q5U820

MASS(Da):168,491

GeneID:492302

Synonyms:ATP-binding cassette sub-family C member 7;cAMP-dependent chloride Channel;CFTR;Channel conductance-controlling ATPase;Cystic fibrosis transmembrane conductance regulator

Gene names:CFTR

Standard solution:2400ng/L