CAMKK2 antibody , Cat. # FNab01238

SKU: FNab01238

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase(AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals(By similarity). Seems to be involved in hippocampal activation of CREB1(By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.

Immunogen:calcium/calmodulin-dependent protein kinase kinase 2, beta

Synonyms:CAMKKB, KIAA0787

Observed MW:55-60 kDa

Uniprot ID:Q96RR4

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IF, IHC

Recommended dilution:WB: 1:500-1:2000; IF: 1:20-1:200; IHC: 1:20-1:200

Gene ID:10645

Research Area:Neuroscience, Signal Transduction, Metabolism