CALR Polyclonal Antibody

SKU: E-AB-14113

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: CALR

Target Synonym: Autoantigen RO;CALR;CALR protein;CALR;Calregulin;Calreticulin;cC1qR;CRP55;CRT;CRTC;Endoplasmic reticulum resident protein 60;Epididymis secretory sperm binding protein Li 99n;ERp60;FLJ26680;grp60;HACBP;HEL S 99n;RO;Sicca syndrome antigen A (autoantigen Ro;calreticulin);Sicca syndrome antigen A;SSA

Research Areas: Cancer;Signal Transduction;Tags and Cell Markers

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P27797

Accession:

Background: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.

Concentration: 0.2 mg/mL

Immunogen: Recombinant protein of human CALR

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: WB 1:1000-1:5000;IHC 1:50-1:200

Calculated MW: 48kDa

ObservedMW: