CAD Polyclonal Antibody

SKU: E-AB-19652

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: CAD

Target Synonym: Aspartate carbamoyltransferase;Aspartate transcarbamylase;CAD protein;CAD trifunctional protein;Carbamoyl phosphate synthetase 2;Carbamoyl-phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase;CPSase ATCase DHOase;Dihydroorotase;Glutamine dependent carbamoyl phosphate synthase;Multifunctional protein CAD

Research Areas: Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Metabolism

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P27708

Accession:

Background: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.

Concentration: 0.7 mg/mL

Immunogen: Synthetic peptide of human CAD

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:40-1:200

Calculated MW:

ObservedMW: