Bovine Triggering Receptor Expresses On Myeloid Cells-1, TREM-1 ELISA Kit

SKU: E2257Bo

Size:96 Tests-1 Kit

Background:Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of proinflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis.

Research_area:Others

Applications:ELISA

Target_protein:TREM1

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:2.59ng/L

Detection range:5-1000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Triggering Receptor Expresses On Myeloid Cells-1

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q6QUN5

MASS(Da):25,381

GeneID:404547

Synonyms:CD antigen CD354;TREM 1;TREM1;TREM-1;Triggering receptor expressed on myeloid cells 1

Gene names:TREM1

Standard solution:1280ng/L