Bovine polymeric immunoglobulin receptor-secretory component,PIGR-SC ELISA KIT

SKU: E0155Bo

Size:96Tests

Background:[Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. {ECO:0000250|UniProtKB:P01833}.; [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells. {ECO:0000250|UniProtKB:P01833}.

Research_area:

Applications:ELISA

Target_protein:PIGR

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:1.07ng/ml

Detection range:1.88-120ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:polymeric immunoglobulin receptor;secretory component

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P81265

MASS(Da):82435

GeneID:281401

Synonyms:PIGR

Gene names:PIGR

Standard solution:240ng/ml