Bovine Oxidized low-density lipoprotein receptor 1,OLR1;LOX1 ELISA KIT

SKU: E0180Bo

Size:96 Tests-1 Kit

Background:Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. {ECO:0000269|PubMed:10618423, ECO:0000269|PubMed:10777555, ECO:0000269|PubMed:11290792, ECO:0000269|PubMed:11821070, ECO:0000269|PubMed:9052782, ECO:0000269|PubMed:9689115}.

Research_area:

Applications:ELISA

Target_protein:OLR1

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:0.02ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Oxidized low-density lipoprotein receptor 1

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P79391

MASS(Da):30892

GeneID:281368

Synonyms:OLR1 LOX1

Gene names:OLR1

Standard solution:16ng/ml