Bovine Interleukin-12 Subunit Beta, IL12B ELISA Kit

SKU: E2225Bo

Size:96 Tests-1 Kit

Background:Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).

Research_area:Immunology

Applications:ELISA

Target_protein:IL12B

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:5.31ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin-12 Subunit Beta

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P46282

MASS(Da):37,050

GeneID:281857

Synonyms:CLMF p40;Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL 12B;IL 12beta;IL-12 subunit p40;IL12B;IL-12B;Interleukin-12 subunit beta

Gene names:IL12B

Standard solution:2400ng/L